Not to be confused with ionotropic. An inotrope is an agent that alters the force or drugs acting on cardiovascular system pdf of muscular contractions.
Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction. However, it can also refer to pathological conditions. Both positive and negative inotropes are used in the management of various cardiovascular conditions. The choice of agent depends largely on specific pharmacological effects of individual agents with respect to the condition. One of the most important factors affecting inotropic state is the level of calcium in the cytoplasm of the muscle cell. While it is often recommended that vasopressors are given through a central line due to the risk of local tissue injury if the medication enters the local tissue, they are likely safe when given for less than two hours in a good peripheral iv.
By increasing the concentration of intracellular calcium or increasing the sensitivity of receptor proteins to calcium, positive inotropic agents can increase myocardial contractility. These channels respond to voltage changes across the membrane differently: L-type channels respond to higher membrane potentials, open more slowly, and remain open longer than T-type channels. Because of these properties, L-type channels are important in sustaining an action potential, while T-type channels are important in initiating them. By increasing intracellular calcium, via the action of the L-type channels, the action potential can be sustained for longer and therefore, contractility increases. Negative inotropic agents decrease myocardial contractility and are used to decrease cardiac workload in conditions such as angina. The word inotrope is ISV via New Latin, from Greek in-, fibre or sinew, plus -trope, turning or moving.
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Houghton Mifflin Harcourt, The American Heritage Dictionary of the English Language, Houghton Mifflin Harcourt. Elsevier, Dorland’s Illustrated Medical Dictionary, Elsevier. Wolters Kluwer, Stedman’s Medical Dictionary, Wolters Kluwer. A systematic review of extravasation and local tissue injury from administration of vasopressors through peripheral intravenous catheters and central venous catheters”. Use of inotropes in critical care”.
This page was last edited on 4 April 2018, at 23:46. This article is about the group of cholesterol-lowering drugs. For the amino acid, see Statine. For inhibiting hormones, see Releasing and inhibiting hormones. Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications. Side effects of statins include muscle pain, increased risk of diabetes mellitus, and abnormalities in liver enzyme tests. Additionally, they have rare but severe adverse effects, particularly muscle damage.